Michigan State University has a world class serious game development program, titled Games for Entertainment & Learning Lab.
They write: The mission of the Games for Entertainment and Learning (GEL) Lab at Michigan State University is to design innovative prototypes, techniques, and complete games for entertainment and learning and to advance state of the art knowledge about social and individual effects of digital games. The GEL Lab is an association of game research and design faculty and students at Michigan State University, primarily in the College of Communication Arts and Sciences. The lab does externally funded research and development work and employs several graduate and undergraduate students.
Visit their website here: http://www.gel.msu.edu